Pantoprazole is recommended when inhibiting acid secretion is therapeutically beneficial, i.e. Stomach ulcer disorders. Illnesses caused by gastroesophageal reflux. Non-steroidal anti-inflammatory drug-induced ulcer (NSAIDs) Helicobacter pylori eradication (in combination with antibiotics) Syndrome of Zollinger-Ellison

Proton Pump Blocker.

Pantoprazole is a proton pump inhibitor that works by covalently attaching to the H+/K+ATPase enzyme system on the surface of the gastric parietal cell to decrease the last stage of gastric acid generation. Regardless of the stimulus that remains for more than 24 hours, this impact results in a suppression of both basal and induced stomach acid secretion.

Oral: Benign gastric ulcer: 40 mg daily in the morning for 4 weeks, continued for further 4 weeks, if not fully healed. Gastro-esophageal reflux disease: 20-40 mg daily in the morning for 4 weeks, continued for further 4 weeks, if not fully healed; maintenance dose is 20 mg daily, which may be increased to 40 mg daily. Duodenal ulcer: 40 mg daily in the morning for 2 weeks, continued for further 2 weeks if not fully healed. Duodenal ulcer associated with Helicobacter pylori: Pantoprazole is recommended at a dose of 40 mg twice daily in association with antimicrobial agents as detailed below: Amoxycillin 1 g and Clarithromycin 500 mg both twice daily for one week, or Clarithromycin 250 mg and Metronidazole 400 mg both twice daily for one week. Prophylaxis of NSAID-associated gastric or duodenal ulcer: 20 mg daily for those require long-term NSAID treatment. Zollinger-Ellison Syndrome: Initially 80 mg once daily adjusted according to response (elderly max. 40 mg daily); daily doses above 80 mg given in 2 divided doses. IV Injection: Duodenal ulcer and gastric ulcer: 40 mg once daily for 7-10 days Gastroesophageal reflux disease associated with a history of erosive esophagitis: 40 mg once daily for 7-10 days Prevention of rebleeding in peptic ulcer: IV 80 mg, followed by 8 mg/hour infusion for 72 hours Prophylaxis of acid aspiration: 80 mg IV every 12 h for 24 h, followed by 40mg every 12 hour Long-term management of Zollinger-Ellison Syndrome and other pathological hypersecretory conditions: 80 mg IV every 12 hours, may increase to 80 mg every 8 hours if needed, may titrate to higher doses depending on acid output.

In clinical investigations, no significant medication interactions were found.

Those with known hypersensitivity to any of the formulation's ingredients should not take pantoprazole.

Both in the short-term and the long-term, pantoprazole is well tolerated. The most frequent adverse effects are headache and diarrhea, while abdominal pain, flatulence, rash, sleeplessness, and hyperglycemia are only rarely reported side effects.

Pantoprazole is classified as a B pregnancy drug by the US FDA. Nevertheless, there isn't any good, controlled research on pregnant women. This medication should only be used during pregnancy if clearly necessary, as a human response to treatments is not usually predicted by studies on animal reproduction. It has been demonstrated that pantoprazole is excreted in human milk. So, a choice should be taken on whether to stop nursing or stop taking the medication, taking into account the benefit of the medication to the mother.

Patients should be advised not to split, chew, or crush the Pantoprazole pill. The use of Pantoprazole for an extended period of time may cause malabsorption of cyanocobalamin (Vitamin B12) or raise the risk of problems linked to osteoporosis.

There are no recognized signs of human overdose. Due to its strong protein binding, pantoprazole is not easily dialyzable. There is no specific therapy that is advised, other symptomatic and supportive management.

Keep dry and away from heat and light. Keep out of children's reach.