Progut MUPS 20 mg
Esomeprazole
Category: MUPS Tablet
Manufacturer: Popular Pharmaceuticals Ltd.
Price: 11.0 ৳
Piece
50's Pack
Related Medicines
Progut MUPS is indicated:
Treatment of Gastroesophageal Reflux Disease (GERD)
Healing of erosive esophagitis
Maintenance of healing of erosive esophagitis
Symptomatic Gastroesophageal Reflux Disease (GERD)
Reduction of NSAID-associated gastric ulcer
H. pylori eradication (Triple therapy)
Zollinger-Ellison syndrome।
Proton Pump Inhibitor
Esomeprazole exerts its stomach acid-suppressing effects by preventing the final step in gastric acid production by covalently binding to sulfhydryl groups of cysteines found on the H+/K+-ATPase enzyme at the secretory surface of gastric parietal cells. This effect leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus. As the binding of esomeprazole to the H+/K+-ATPase enzyme is irreversible and new enzyme needs to be expressed in order to resume acid secretion, esomeprazole's duration of antisecretory effect that persists longer than 24 hours
Esomeprazole appears to be a selective inhibitor of the cytochrome P450 mono-oxygenase system, there may be an effect on hepatic clearance, but there have been no reports to date of clinically relevant interactions. There is some uncertainty over the effect of Esomeprazole on the oral combined contraceptive pill. Physiological changes similar to those found with omeprazole are likely to take place because of the reduction in gastric acid which is likely to influence the bacterial colonization of the stomach and duodenum and also vitamin B12 absorption.
Esomeprazole is contraindicated in those patients who have known hypersensitivity to any other components of the formulation.
Side effects reported with Esomeprazole include headache, diarrhea and abdominal pain.
US FDA pregnancy category of Esomeprazole is C. So, Esomeprazole should be avoided in pregnancy and lactation unless the potential benefits to the other outweigh the possible risks to the fetus.
Exclude the possibility of malignancy when gastric ulcer is suspected and before treatment for dyspepsia. When using in combination with antibiotic, refer to the prescribing information of the respective antibiotics.
Keep in dry place and away from light and heat. Keep out of the reach of children.
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